缺血性脑血管病患者血浆内皮素水平昼夜节律变化的研究

应用放射免疫法测定了３２例急性期（３天内）脑血栓患者和短暂性脑缺血发作（ＴＩＡ）患者２３例２４ｈ血浆内皮素（ＥＴ）水平变化，发现脑血栓急性期ＥＴ含量显著高于正常对照组（Ｐ＜０．００１），也明显高于ＴＩＡ组（Ｐ＜０．０１）；ＴＩＡ组明显高于对照组（Ｐ＜０．０１）。血浆ＥＴ水平２４ｈ有节律性变化，即夜间２∶００时最低，早８∶００时最高，二者有显著性变化（Ｐ＜０．０１）；有高血压、糖尿病史脑血栓患者２４ｈ内各时间段ＥＴ水平明显高于无高血压、糖尿病史者（Ｐ＜０．０５０．０１）。脑血栓患者血浆ＥＴ水平２４ｈ内节律性变化与之发病以早晨为高发时间段的现象在时间上有同步关系，可能存在着因果关系，即ＥＴ可能是导致脑血栓的原因之一

Circadian Variation of Plasma Immunoreactive Endothelin Concentration of Patients with Ischemic Cerebrovascular Diseases

To explore the circadian variation of plasma immunoreactive endothelin (ET) level in patients with ischemic cerebrovascular disease and the relationship between change of ET level and onset of patients with ischemic cerebrovascular disease. Methods: Using a radioimmunoassy(RIA), the plasma immunoreactive ET level were determined dynamically in 32 patients with cerebral thrombosis(within 3 days) and 23 patients with transient ischemic attack(TIA) at 2∶00am, 8∶00am, 2∶00pm, 8∶00pm during 24 hours. Results: Plasma ET levels were significantly higher in patients with cerebral thrombrosis than in controls(P<0.001), than in patients with TIA(P<0.01). ET level was highest at 8∶00am, and lowest at 2∶00am. There was significantly difference between the ET level at two time points(P<0.01). ET levels in patients with mellitus diabetes and/or hypertension were higher than those without mellitus diabetes and hypertension(P<0.05～0.01). Conslusions: plasma ET levels in patients with acute cerebral thrombosis and TIA increased singnificantly and periodic change was presented regularly within 24 hours. Circadian variation of ET levels was in according with the time of ischemic cerebrovascular disease onset. ET may be one of important factor leading to ischemic cerebrovascular diseases.