降钙素原在诊断早期细菌感染中的价值分析

目的：分析降钙素原在细菌性感染中的诊断价值。方法对有感染症状的住院患者采集静脉血检测降钙素原(Procalcitonin，PCT)，并进行血培养或采集相应感染部位标本进行细菌培养鉴定；将培养致病菌阳性的结果分为脓毒血症组和局部感染组；以正常健康人为阴性对照组；t检验分析各组所得结果，采用R0C曲线评价PCT诊断早期细菌感染的价值。结果脓毒血症组和局部感染组的PCT浓度明显高于对照组PCT浓度水平。脓毒血症组和对照组PCT浓度有统计学差异(P<0.05)；局部感染组和对照组PCT浓度也有统计学差异(P<0.05)。PCT的ROC曲线下面积为0.985，最佳临界值取0.06ng/ml时，其辅助诊断细菌感染灵敏度和特异性分别为97.4%%和93.3%。结论降钙素原是感染的重要指标，不仅能早期预测脓毒血症，也能早期预测其他局部感染。

The diagnostic value of procalcitonin in Bacterial infection

Objective To analyze the diagnostic value of procalcitonin in Bacterial infection.Methods To patients admitted to hospital with clinical symptoms of infection collect their venous blood to detect PCT, and collect the corresponding site of infection specimens for culture and identification; Further cultured pathogen-positive results are grouped based on clinical manifestations, divided into sepsis（blood culture positive or clear clinical diagnosis） and local infection（not sepsis, but there is a partial positive bacterial culture）; Negative control group are 30 normal healthy people, and collected their blood to detect PCT; The results between groups were analyzed by t test. ROC curve to evaluate the value of early diagnosis of bacterial infection. Results PCT concentration of the bacteria positive group was significantly higher than control group. T-test shows a significant difference between culture-positive group（Sepsis group and local infection group） and control group. The area under ROC curve of PCT concentration was 0.985, when the best critical value was 0.06ng/ml, the sensitivity and specificity of auxiliary diagnosis of bacterial infection were 97.4% and 93.3%, respectively. Conclusion PCT was originally an important indicator of infection, it can not only early predict sepsis, but also predict other local infection.