甘芍胶囊治疗耐克罗米芬性多囊卵巢综合征的临床研究

目的评价甘芍胶囊（GSC）治疗耐克罗米芬（CC）、高雄激素血症多囊卵巢综合征（PCOS）患者的有效性、安全性，探索停药后CC改善促排卵效果的可行性。方法给27例PCOS患者服GSC，共8周（2个月经周期）。服药前、服药4周及8周末，观察血清生殖激素、体重指数（BMI）、盆腔超声相的变化及不良反应。停药后，将血清睾酮（T）〈（2．1±0．8）nmol／L的未排卵者再行CC促排卵，监测卵泡发育及效果。结果服药4周末，血清生殖激素均有显著变化。服药8周末，双侧卵巢体积、卵泡数及卵泡直径均显著减小，子宫内膜明显变薄。停中药2个月内，27例中6例自然排卵，2例自然妊娠。19例37个周期行CC促排卵，17例25个周期排卵，7例妊娠，排卵率89．5％，排卵周期率67．6％，妊娠率36．8％，妊娠周期率28．0％。结论采用GSC治疗耐CC、高雄激素血症PCOS患者，可使子宫内膜、卵巢形态及BMI得到明显改善，并提高耐CC者对CC促排卵的敏感性．

Clinical Study of Ganshao Capsule in Treating Clomiphene-resistant Polycystic Ovarian Syndrome

OBJECTIVE: To assess the efficacy and safety of Ganshao Capsule (GSC) in treating clomiphene (CC)-resistant hyperandrogenemic polycystic ovarian syndrome (PCOS), and to explore the feasibility of using CC for improving ovulation induction after withdrawal of GSC. METHODS: Twenty-seven PCOS patients were given GSC for 8 weeks (2 cycles). Changes in serum reproductive hormone, body mass index (BMI), adverse reaction, as well as pelvic ultrasonographic feature were observed before treatment, at the end of 4 weeks and 8 weeks after treatment. After stopping GSC medication, CC was used to induce ovulation in patients whose serum testosterone (T) < (2.1+/-0.8) nmol/L but without ovulation. Condition of follicle growth and effect of GSC were monitored. RESULTS: After 4 weeks of treatment, serum reproductive hormones were significantly changed. At the end of 8 weeks, bilateral ovarian volume, number of follicles, and diameter of follicles were significantly reduced, and endometrium obviously thinned. Within 2 months after stopping medication, 6 in the 27 patients got natural ovulation, and 2 natural pregnancy. In the other 19 patients who received ovulation induction during the 37th cycles, 17 had ovulation in the 25th cycles, 7 got pregnancy, the ovulation rate being 89.5%, ovulation cycle rate 67.6%, pregnant rate 36.8%, and pregnant cycle rate 28.0%. CONCLUSION: Endometrium, ovarian morphology and BMI got significant improvement in PCOS patients with CC- resistance and hyperandrogenemia. The sensitivity to ovulation induction with CC were also improved.