Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus |
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| Authors: | Albright Craig D Mar Mei-Heng Craciunescu Corneliu N Song Jiannan Zeisel Steven H |
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| Affiliation: | Department of Nutrition, CB#7461, Room 2212 McGavran-Greenberg Hall, School of Public Health and School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. |
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| Abstract: | Alterations in maternal dietary choline availability during days 12-17 of pregnancy led to an increase in the level of immunoreactive netrin-1 and a decrease in the level of DCC protein in the developing fetal mouse brain hippocampus compared with controls. Changes in the expression of cell migration cues during development could account for some of the lifelong consequences of maternal dietary choline availability for cognitive and memory processes. |
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