POEMS综合征四例并文献复习

 目的　探讨POEMS综合征的临床特征及治疗方法。方法　对4例POEMS综合征患者临床资料、相关检查及治疗方法进行回顾性分析。结果　4例患者均有多发性神经病、异常球蛋白血症及内分泌异常，其他症状还有浆膜腔积液、肝脾大等。患者均给予激素、环磷酰胺及沙利度胺治疗及应用人血免疫球蛋白静脉滴注等。结论　POEMS综合征是一种少见的多脏器损害疾病，较难诊断。临床上对可疑病例需进行密切观察及必要的检查，以免误诊。治疗并无特效药物，尚处于探讨阶段。

Clinical analysis of 4 patients with POEMS syndrome

Objective To evaluate the clinical features of POEMS syndrome. Methods The clinical materials of 4 patients with POEMS syndrome were analysed retrospectively. Results All 4 patients presented polyneuropathy, abnormal globulinemia and endocrinopathy. All were treated with corticoid, cyclophosphamide and thalidomide. Some patients were treated with human immunoglobulin. Conclusion POEMS syndrome was a rare disease with involvement of multiorgan which result in difficult diagnosis. So for suspected cases, a necessary examination to avoid misdiagnosis should be given.