| 胎肝低分子抑瘤物和维生素A酸对HL-60细胞中c-myc癌基因表达的影响 |
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| 引用本文： | 刘景梅,邢桂春,薛惠华,吴祖泽.胎肝低分子抑瘤物和维生素A酸对HL-60细胞中c-myc癌基因表达的影响[J].军事医学科学院院刊,1991(2). |
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| 作者姓名： | 刘景梅 邢桂春 薛惠华 吴祖泽 |
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| 作者单位： | 军事医学科学院放射医学研究所，军事医学科学院放射医学研究所，军事医学科学院放射医学研究所，军事医学科学院放射医学研究所 |
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| 摘 要： | 胎肝中存在着一类低分子抑瘤物,可明显抑制 HL-60细胞的增殖。为探讨其作用机制,本实验对 HL-60细胞经胎肝低分子抑瘤物和维生素 A 酸作用后 c-myc 癌基因的表达水平进行了检测。结果表明,维生素 A 酸可明显抑制 HL-60细胞中 c-myc 基因的表达,而胎肝低分子抑瘤物却无明显作用。
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| 关 键 词： | 胎肝低分子抑瘤物 维生素 A 酸 癌基因 c-myc |
COMPARISON OF c-myc GENE EXPRESSION IN HL-60 LEUKEMIA CELLS BY RA AND A LOW MOLECULAR TUMOR SUPPRESSOR OF HUMAN FETAL LIVER ORIGIN |
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| Liu Jingmei Xing Guichun Xue Huihua Wu Zuze.COMPARISON OF c-myc GENE EXPRESSION IN HL-60 LEUKEMIA CELLS BY RA AND A LOW MOLECULAR TUMOR SUPPRESSOR OF HUMAN FETAL LIVER ORIGIN[J].Bulletin of the Academy of Military Medical Sciences,1991(2). |
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| Authors: | Liu Jingmei Xing Guichun Xue Huihua Wu Zuze |
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| Abstract: | HL-60 cell line,derived from a patient with promyelocytic leukemia,can be induced to differentiate in vitro to granulocyte or monocyte/macrophage in the presence of a specific inducing agent such as DMSO,TPA,RA or others.Therefore,HL-60 cells provide an invaluable model system for studying the oncogene structure and its expression under various conditions.In this paper we studied the effect of RA and a newly developed low molecular tumor suppressor isolated from human fetal liver on the expression of c-myc in HL-60 cells. The results indicated that c-myc mRNA level decreased markedly in differentiating HL-60 cells treated with RA.However,under the similar culture system c-myc mRNA level did not change when HL-60 cells were cultured in vitro in the presence of low molecular tumor suppressor of human fetal liver origin. |
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| Keywords: | low molecular tumor suppressor of human fetal liver retinoic acid oncogene c-myc |
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