| 前列腺癌干细胞与去势抵抗性前列腺癌放射性耐受的研究进展 |
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| 引用本文： | 朱逸飞,曾浩.前列腺癌干细胞与去势抵抗性前列腺癌放射性耐受的研究进展[J].中华放射肿瘤学杂志,2017,26(11):1347-1349. |
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| 作者姓名： | 朱逸飞 曾浩 |
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| 作者单位： | 830001 乌鲁木齐,新疆自治区人民医院泌尿中心(朱逸飞);610041 成都,四川大学华西医院泌尿外科(曾浩) |
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| 基金项目： | 四川省科技厅项目(2015SZ0230)Fund program:Project of Sichuan Department of Science and Technology(2015SZ0230) |
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| 摘 要： | 前列腺癌经过去势治疗后有进展为去势抵抗性前列腺癌的可能。去势抵抗性前列腺癌对临床医生最大的挑战为其治疗抵抗特性。针对放疗耐受,相关研究认为与前列腺癌干细胞及前列腺癌干细胞相关miRNA相关。下文从去势抵抗性前列腺癌进展机制、前列腺癌干细胞及前列腺癌干细胞相关miRNA等方面介绍去势抵抗性前列腺癌放射性耐受的研究进展。
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| 关 键 词： | 去势抵抗性前列腺癌 前列腺癌干细胞 放射性耐受 微小核糖核酸 |
| 收稿时间： | 2016-11-07 |
Research advances in prostate cancer stem cells and radiotherapy resistance of castration-resistant prostate cancer |
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| Zhu Yifei,Zeng Hao.Research advances in prostate cancer stem cells and radiotherapy resistance of castration-resistant prostate cancer[J].Chinese Journal of Radiation Oncology,2017,26(11):1347-1349. |
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| Authors: | Zhu Yifei Zeng Hao |
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| Institution: | Department of Urology,Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China (Zhu Yifei);Department of Urology,West China Hospital,Chengdu 610041,China (Zeng Hao) |
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| Abstract: | Prostate cancer tends to progress to castration-resistant prostate cancer within 24 months after castration. For the management of castration-resistant prostate cancer, the biggest challenge is therapeutic resistance which includes radiotherapy resistance. Relevant studies suggest that the radiotherapy resistance of castration-resistant prostate cancer is associated with prostate cancer stem cells and miRNA related to prostate cancer stem cells. This article reviews the research advances in the radiotherapy resistance of castration-resistant prostate cancer in terms of the possible mechanisms of castration-resistant prostate cancer,prostate cancer stem cells,and miRNA related to prostate cancer stem cells. |
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| Keywords: | Castration Resistant Prostate Cancer Cancer stem cell Prostate cancer stem cell Micro-ribonucleic acid |
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