金纳米颗粒在肿瘤放射增敏中的相关研究进展

纳米技术被广泛用于肿瘤的诊断和治疗中,逐渐成为研究的热点。在纳米材料中金纳米颗粒由于低毒性、较好的生物相容性及增强的穿透滞留效应等独特优势在肿瘤诊断、成像、治疗等领域受到广泛关注。目前多项研究表明金纳米颗粒可作为理想的放射增敏剂,研究其在体内、外放射增敏作用将对纳米医学的临床转化具有重要意义。

Research advances in gold nanoparticle-mediated tumor radiosensitization

Nanotechnology has been extensively applied in the diagnosis and treatment of cancer, and is currently a major focus of research worldwide.Among the various nanomaterials, gold nanoparticles (GNPs) are of particular interest to many researchers due to their superior properties of low cytotoxicity, good biocompatibility, and preferential accumulation in tumors (the "enhanced permeability and retention" effect), which in turn gives GNPs a potential application in cancer diagnostics, imaging, photothermal therapy, and radiotherapy.Many published studies have shown that GNPs can be used as a new ideal radiosensitizer, and therefore understanding the radiosensitizing effects of GNPs both in vitro and in vivo will be of great significance in the clinical translation of nanomedicine.