妇科肿瘤伴腹主动脉旁淋巴节转移IMRT靶区勾画探讨

目的 初步探讨妇科肿瘤伴腹主动脉旁淋巴节转移患者IMRT的CTV勾画范围。方法 回顾分析2010—2016年收治的56例妇科肿瘤伴腹主动脉旁淋巴结转移患者。通过影像学方法判断腹主动脉旁转移淋巴结数目和分布情况。结果 56例妇科肿瘤患者腹主动脉旁淋巴结转移共计108个,平均每位患者转移淋巴结数目为2个(1~4个),腹主动脉旁转移淋巴结平均直径为2.3 cm (1.2~4.0 cm)。20个(19%)淋巴结位于L₄水平,38个(35%)转移淋巴结位于L₃水平,44个(41%)转移淋巴结位于L₂水平,6个(5%)位于L₁水平。腹主动脉旁左侧组转移淋巴结共71个(66%)。腹主动脉-腔静脉间组转移淋巴结共20个(19%)。下腔静脉旁右侧组转移淋巴结共17个(15%)。结论 妇科肿瘤腹主动脉旁淋巴结勾画不应以血管周围外扩固定范围方式勾画,腹主动脉旁左侧应充分勾画在靶区范围内,靶区上界应至肾动脉水平,对肾动静脉旁有淋巴结转移者靶区上界应适当扩展。

Delineation of target volume in intensity-modulated radiotherapy for para-aortic lymph node metastases in patients with gynecological malignancies

Objective To preliminarily explore the delineation of clinical target volume in intensity-modulated radiotherapy for para-aortic lymph node metastases in patients with gynecological malignancies.Methods A retrospective analysis was performed on 56 gynecological tumor patients with para-aortic lymph node metastases who were admitted to our department from January 2010 to September 2016.The number and distribution of metastatic para-aortic lymph nodes were determined by imaging method.Results A total of 108 positive para-aortic lymph nodes were found in the 56 patients,with 1-4(mean,2) positive para-aortic lymph nodes per patient.The mean diameter of positive para-aortic lymph nodes was 2.3 cm (1.2-4.0 cm).A total of 20 metastatic lymph nodes (19%) were located at the L4 level,38(35%) at the L3 level,44(41%) at the L2 level,and 6(5%) at the L1 level.There were 71 metastatic lymph nodes (66%) at the left side of the para-aortic region,20 metastatic lymph nodes (19%) between the abdominal aorta and the vena cava,and 17 metastatic lymph nodes (15%) at the right side of the inferior vena cava.Conclusions For patients with gynecological malignancies,nodal contouring for the para-aortic region should not be defined by a fixed circumferential margin around the vessels.The left side of the para-aortic region should be covered adequately;the upper target should be extended up to the renal artery,and needs to be further extended for patients who have nodal involvement near the renal arteries and veins.