癫痫持续状态预后评分进展

癫痫持续状态具有较高的死亡率，是神经内科常见的危急重症。对患者预后风险进行评估，对其病情严重程度进行准确分级将有助于临床医师制定个体化的治疗方案，最大限度地使癫痫持续状态患者获益。目前国际上共有4个癫痫持续状态预后风险的评分：癫痫持续状态严重程度评分（status epilepticus severity score，STESS）、基于流行病学死亡率的癫痫持续状态评分（epidemiologybased mortality score in SE，EMSE）、改良癫痫持续状态严重程度评分（modified STESS，mSTESS）以及END-IT评分[包括脑炎与否（Encephalitis）、是否合并非惊厥性癫痫持续状态（Nonconvulsive statusepilepticus，NCSE）、是否有地西泮抵抗（Diazepam resistance）、神经影像学特征（Image）以及是否进行气管插管（Tracheal intubation）]。本文回顾了癫痫持续状态预后评分的进展，简述了每个评分的建立过程及其优势和局限性，以期增强临床医师对癫痫持续状态预后评分的认识、裨益临床研究。

Advances in Prognostic Scores of Status Epilepticus

Status epilepticus (SE) is a common and life-threatening neurological emergency disease with a high mortality rate. An accurate patient stratification and outcome prediction will assist physicians to optimize individualized medical intervention strategies and bring utmost benefits for patients with SE. There are four prognostic scores in SE: the Status Epilepticus Severity Score (STESS), the Epidemiology based Mortality score in SE (EMSE), the modified STESS (mSTESS), and the END-IT score. This paper reviewed the advances in prognostic scores of SE, presented their design methods, and analyzed advantages and limitations of each score, with the aim to facilitate better clinical assessment and research of SE prognostic scores.