中国北方地区汉族人冠心病患者血清胆固醇酯转运蛋白的水平

为分析冠心病患者血清胆固醇酯转运蛋白的水平 ,采用病例—对照研究胆固醇酯转运蛋白与血脂、脂蛋白和载脂蛋白水平的相关性。应用酶联免疫吸附试验测定 10 6例冠心病患者和 6 4例正常对照者血清胆固醇酯转运蛋白浓度 ,结果分别为 2 .15± 0 .90mg L和 2 .31± 1.0 8mg L ,两者差异无显著性 (P >0 .0 5 )。相关分析显示 ,血清胆固醇酯转运蛋白浓度与其他血脂和脂蛋白水平无显著相关性 (P >0 .0 5 )。以上提示 ,血清胆固醇酯转运蛋白水平不是中国北方地区汉族人冠心病发生的主要危险因素。

Serum Cholesteryl Ester Transfer Protein Levels in Patients with Coronary Heart Disease in Han Nationality from Northern China

Aim To determine the serum cholesteryl ester transfer protein(CETP) level in patients with coronary heart disease(CHD) in Han nationality and explore its association with serum lipids, lipoproteins and apolipoproteins levels. Methods To undertake a case control study, we detected the serum CETP level in 64 unrelated healthy individuals and 106 patients with evidence of CHD by enzyme linked immunosorbent assay. Results The results showed that there was not statistically different between patients and controls(2.15±0.90 mg/L vs 2.31±1.08 mg/L ,p>0.05). No significant correlation was found between CETP concentration and lipids and lipoproteins concentration(p>0.05). Conclusions There is no significant relation between serum CETP level and CHD in Han nationality from northern China.