308nm准分子激光治疗对白癜风患者外周血Th1及Th2细胞因子的影响

目的：研究308 nm准分子激光对白癜风患者外周血Th1型细胞因子干扰素γ（ IFN-γ）和Th2型细胞因子白细胞介素-4（ IL-4）水平的影响，探讨其可能的作用机制。方法50例白癜风患者均采用308 nm准分子激光治疗，每周2次共治疗24次。采用酶联免疫吸附法（ ELISA法）检测50例白癜风患者治疗前、后及20例正常健康者外周血IFN-γ及IL-4的水平，并统计临床疗效。结果治疗组治疗前IFN-γ水平较正常对照组升高，比较差异有统计学意义（P＜0．05）；治疗后较治疗前明显降低（P＜0．05），且与正常对照组比较差异无统计学意义（P＞0．05）。治疗组治疗前IL-4水平与正常对照组及本组治疗后比较差异均无统计学意义（ P＞0．05）。结论白癜风患者体内Th1型细胞因子占优势，308 nm准分子激光可恢复白癜风患者Th1及Th2的平衡状态。

Effect of 308nm excimer laser therapy on Th1/Th2 cytokines in peripheral blood of patients with vitiligo

Objective To study the level of Th1 cytokine（IFN-γ） and Th2 cytokine （IL-4） in peripher-al blood of patients with vitiligo , and to explore the possible immune mechanism of 308 nm excimer laser for vitiligo therapy.Methods 50 cases of vitiligo were treated by 308nm excimer laser therapy , twice a week for 24 times.The level of IFN-γand IL-4 in peripheral blood from 50 vitiligo patients before and after treatment and 20 healthy per-son in control group were measured by enzyme linked immunosorbent assay .Results There was no difference be-tween two groups on the level of IL -4 （P＆gt;0.05）.The level of IFN-γin vitiligo patients was higher than that in the control group （P＆lt;0.05）; After 308nm excimer laser therapy the level of IFN -γin vitiligo patients was dis-creased significanlty （P＆lt;0.05）.There was no significant difference between two groups after treatment （P＆gt;0.05）. Conclusion Th1 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo .308nm ex-cimer laser therapy can restore the Th 1/Th2 balance .