Physiological role of the putative ammonium transporter RhCG in the mouse. |
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| Authors: | S Biver S Scohy J Szpirer C Szpirer B André A-M Marini |
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| Affiliation: | Laboratoire de biologie du développement, institut de biologie et de médecine moléculaires, université libre de Bruxelles CP300, rue des professeurs Jeener-et-Brachet, 12, 6041 Gosselies, Belgium. |
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| Abstract: | Ammonium excretion into urine is a major process essential to the regulation of acid-base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene. |
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