皮肤鳞癌组织HIF-1α和MMP-2表达及意义

目的研究缺氧诱导因子-1α（HIF-1α）、基质金属蛋白酶-2（MMP2）在皮肤鳞癌组织表达及相关性。方法应用免疫组化法检测42例皮肤鳞癌、13例BOWEN病、11例正常皮肤组织中HIF-1α、MMP-2的表达。结果HIF-1α和MMP-2在正常皮肤、BOWEN病及皮肤鳞癌组织中的表达率分别为0、61．54％、73．81％及0、38．46％、50．00％，差异有统计学意义（χ^2=23．675、12．955，P〈0．05）。HIF-1α、MMP-2在皮肤鳞癌和BOWEN病组织中的表达均高于正常皮肤组织，差异有统计学意义（χ^2=16．638、7．139，P〈0．05；P=0．02、0．04）。在皮肤鳞癌组织中HIF-1α与MMP-2的表达呈正相关（χ^2=0．379，P〈0．05）。结论HIF-1α、MMP-2在皮肤鳞癌组织高度表达，且两者的表达密切相关。

EXPRESSIONS OF HYPOXIA-INDUCIBLE FACTOR-1 ALPHA AND MATRIX MATALLOPROTEINASES-2 IN SKIN SQUAMOUSCELL CARCINOMA

Objective To study the expressions of hypoxia-inducible factor-1 alpha （HIF-1α） and matrix matalloprotei- nases-2 （MMP 2） in skin squamous cell carcinoma （SCC） and their correlation. Methods By using immunohistoehemieal me- thod, the expressions of MMP-2 and HIF la, 42 cases of skin SCC, 13 patients with BOWEN＇s disease and 11 normal skin tissue- were detected. Results The expressions of HIF-la and MMP-2 in normal skin, BOWEN＇ s disease and skin SCC were 0, 61.54G, 73.81% and 0, 38.46%, 50.00%, respectively, the differences being statistically significant （χ^2=23. 675,12. 955;P〈 0.05）. The expressions of HIF-lα and MMP-2 in skin SCC and Brown＇s disease were higher than that in normal skin tissue （χ^2= 16. 638,7.139;P%0. 05）. In skin SCC, the expression of HIF-lα was positively correlated with MMP-2 （rs=0.379,P〈0.05）. Conclusion Over expressions of HIF-lα and MMP-2 can be seen in skin SCC,the expressions of these two parameters are closely related in this disease.