幽门螺杆菌感染与慢性胃炎相关性

目的探讨幽门螺杆菌（Hp）感染与慢性胃炎发生及发展相关性。方法对行胃镜检查2 789例慢性胃炎病人的胃镜及病理检查结果进行回顾性分析,研究慢性胃炎与Hp感染关系。结果中老年组（40～87岁）Hp感染发生率明显高于青年组（18～39岁）,差异有显著性（χ2=46.60、29.08,P〈0.01）;不同性别组间Hp感染的发生率差异无显著性（P〉0.05）。活动性胃炎组Hp感染率为99.0%,中重度感染占51.5%,均明显高于非活动性胃炎组（χ2=179.93,P〈0.01）。慢性浅表性胃炎的Hp感染率为83.6%,慢性萎缩性胃炎为95.4%,二者比较差异有显著性（χ2=28.88,P〈0.01）。Hp感染阳性组重度胃炎、肠上皮化生及异型增生的发生率均较Hp阴性组高,差异有显著性（uc=-30.19～-13.17,P〈0.01）。结论慢性胃炎的发生和发展与Hp感染密切相关。

CORRELATION BETWEEN HELICOBACTER PYLORI AND CHRONIC GASTRITIS

Objective To explore the correlation between Helicobacter pylori（Hp） infection and chronic gastritis.Methods Reports of gastroscopy and pathology of 2 789 patients with chronic gastritis were analyzed retrospectively,and the association of chronic gastritis with and Hp was investigated.Results The incidence of Hp infection in middle-and older-age（40-87 years） patients was higher than that in the young（18-39 years） patients（χ2=46.60,29.08;P0.01）,and there was no sex difference in terms of Hp infection（P0.05）.The incidence of Hp infection in active gastritis was 99.0%,in which,moderate to severe cases accounting for 51.5%,all were obviously higher than that in non-active condition（χ2=179.93,P0.01）.The incidences of Hp infection in chronic superficial gastritis and chronic atrophic gastritis were 83.6% and 95.4%,respectively,the difference between them being significant（χ2=28.88,P0.01）.In Hp-positive group,the prevalence of severe gastritis,intestinal metaplasia and atypical hyperplasia was higher than in Hp-negative group（uc=-30.19——13.17,P0.01）.ConclusionThe occurrence and development of chronic gastritis is closely related to Hp infection.