Methadone Toxicity and Possible Induction and Enhanced Elimination in a Premature Neonate |
| |
Authors: | Mathew George Joseph P Kitzmiller Michele Burns Ewald Katherine A O’Donell Melissa Lai Becter Steve Salhanick |
| |
Institution: | 1. Tappan, NY, USA 2. Department of Pharmacology, Columbus, Ohio State University, 5072C Graves Hall, 333 West 10th Avenue, Columbus, OH, 43210, USA 3. Childrens Hospital Boston, Longwood Ave, Boston, MA, 02115, USA
|
| |
Abstract: | Introduction Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate the management of methadone overdose in neonates, and literature involving methadone toxicokinetics and toxicodynamics in pediatric and neonate populations is largely limited. Case Report The clinical course and pharmacologic data of a massive methadone overdose in a 20-day-old male neonate is described, and a contemporary review of developmental pharmacology is presented. Discussion As clinicians continue to use methadone in neonates, they should be aware of the many significant peculiarities regarding its toxicology and pharmacology in that patient population. |
| |
Keywords: | Methadone overdose Premature neonate CYP metabolism Age-related pharmacokinetics Methadone toxicology |
本文献已被 SpringerLink 等数据库收录! |
|