多囊卵巢综合征病人血清CRP、内脂素和chemerin变化及其意义

目的探讨多囊卵巢综合征（PCOS）病人血清C反应蛋白（CRP）、内脂素和chemerin变化及其临床意义。方法根据2003年鹿特丹会议制定的诊断标准选择PCOS病人50例,按体质量指数（BMI）再分为肥胖型组（n=24）与非肥胖型组（n=26）,同时选择22例同龄健康生育期女性作为正常对照组。采用免疫比浊法检测3组血清中CRP水平,采用酶联免疫吸附法（ELISA法）检测血清中内脂素和chemerin水平。结果 PCOS病人肥胖型组和非肥胖型组血清CRP、内脂素和chemerin水平均明显高于正常对照组,肥胖型组血清CRP、chemerin水平明显高于非肥胖型组（F=4.21～11.07,q=3.29～4.88,P〈0.05）。PCOS病人CRP、chemerin与BMI、胰岛素抵抗指数（HOMA-IRI）呈正相关（r=0.34～0.65,P〈0.05）;内脂素与BMI、HOMA-IR无明显相关性（P〉0.05）。结论 PCOS病人体内可能存在慢性炎症,这可能是导致血清CRP、内脂素和chemerin水平升高的原因之一。

CHANGES AND SIGNIFICANCE OF SERUM C-REACTIVE PROTEIN, VISFATIN AND chemerin LEVELS IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Objective To investigate the changes of serum C-reactive protein （CRP）, visfatin and chemerin levels and their significance in patients with polycystic ovarian syndrome （POS）. Methods Fifty women with POS met the diagnostic cri teria of 2003 Rotterdam Conference were enrolled in this study, and divided into obese （24 cases） and non-obese （26 cases） groups based on body mass index （BMI）. A control group consisted of 22 healthy women of the same age. Serum CRP was measured by immunoturbidimetry, visfatin and chemerin were assayed by enzyme-linked immunosorbent assay （ELISA）. Results Serum CRP, visfatin and chemerin in patients, both obese and non-obese, were markedly higher than that in normal controls, and that in the obese group were higher than that in the non-obese group （F= 4.21-11.07, q= 3.29-4.88, P〈0.05）. The levels of CRP and chemerin in the patients were positively correleted with BMI and insulin resistance index （IRI） （r=0.34 0. 65,P〈0.05）, but serum level of visfatin was not obviously associated with CRP, BMI and chemerin. Conclusion Chronic inflammation possi bly exists in patients with POS, which may be one of the reasons that causes the elevation of serum CRP, visfatin and chemerin.