冠心病病人PCI前后Hs-CRP变化及其相关因素

目的探讨能够引起经皮冠状动脉介入治疗（PCI）术后血清超敏C-反应蛋白（Hs-CRP）水平升高的独立危险因素。方法行选择性冠状动脉支架置入术的急性冠状动脉综合征（ACS）病人195例,于术前、术后24h测定血清Hs-CRP水平,计算术后与术前Hs-CRP水平之差（ΔCRP）。根据ΔCRP≤3mg/L和〉3mg/L分为两组,比较两组临床特征,并行ΔCRP的多因素Logistic回归分析。结果两组间高密度脂蛋白、支架个数、支架长度、支架重叠、靶病变类型B2/C、多支病变差异有统计学意义（t=2.059～7.747,χ2=12.333～65.090,P〈0.05、0.01）。ACC/AHA病变分型B2/C、支架长度、支架数目、支架重叠和多支病变是引起ΔCRP升高的独立预测因子。结论 ACC/AHA病变分型B2/C、支架长度、支架数目、支架重叠和多支病变是引起PCI术后Hs-CRP水平升高的独立危险因素。

CHANGES AND RELATIVE FACTORS OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE BEFORE AND AFTER PERCUTANEOUS CORONARY INTERVENTION

Objective To explore the independent risk factors that raise high-sensitivity C-reactive protein（Hs-CRP） level in patients after percutaneous coronary intervention（PCI）. Methods A selective coronary stenting was performed in 195 patients with acute coronary syndrome（ACS）.The serum level of Hs-CRP was detected before and 24 hours after PCI,the difference of Hs-CRP between before and after PCI was calculated.The patients were divided into two groups based on CRP≤3 mg/L and 3 mg/L,the clinical features were compared and multivariate logistic regression analysis done. Results The differences between the two groups were significant in terms of the level of HDL,ACC/AHA type B2/C lesion,length and number of stent,the incidence of stent overlapping and multivessel stenting（t=2.059-7.747;χ2=12.333-65.090;P〈0.05,0.01）,all the above items were independent predictors of high Hs-CRP. Conclusion The independent risk factors responsible for increasing post-PCI Hs-CRP are ACC/AHA type B2/C lesion,length and number of stent,stent overlapping and multivessel stenting.