| 高效液相色谱法测定复方醋酸曲安奈德溶液中醋酸曲安奈德含量 |
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| 引用本文： | 胡斌,林彩,赵映兰,邓莉,秦露. 高效液相色谱法测定复方醋酸曲安奈德溶液中醋酸曲安奈德含量[J]. 中国药业, 2010, 19(21): 26-27 |
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| 作者姓名： | 胡斌 林彩 赵映兰 邓莉 秦露 |
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| 作者单位： | 第三军医大学西南医院药剂科,重庆,400038 |
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| 摘 要： | 目的建立测定复方醋酸曲安奈德溶液中醋酸曲安奈德含量的高效液相色谱法。方法采用DiamonsilTM C18柱（200mm×4.6mm,5μm）,流动相为乙腈-水（60：40）,检测波长240nm,流速1.0mL/min,柱温30℃,进样量10μL。结果醋酸曲安奈德进样量在5.88～15.68μg范围内与峰面积线性关系良好,r=0.9999（n=6）,平均回收率为100.43%,RSD为0.28%（n=9）。结论高效液相色谱法测定复方醋酸曲安奈德溶液中醋酸曲安奈德含量简便、准确、重现性好,能满足医院制剂质量标准的要求。
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| 关 键 词： | 醋酸曲安奈德 复方醋酸曲安奈德溶液 高效液相色谱法 含量测定 |
Determination of Triamcinolone Acetonide Acetate in Compound Triamcinolone Acetonide Acetate Solution by HPLC |
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| Hu Bin,Lin Cai,Zhao Yinglan,Deng Li,Qin Lu. Determination of Triamcinolone Acetonide Acetate in Compound Triamcinolone Acetonide Acetate Solution by HPLC[J]. China Pharmaceuticals, 2010, 19(21): 26-27 |
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| Authors: | Hu Bin Lin Cai Zhao Yinglan Deng Li Qin Lu |
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| Affiliation: | (Department of Pharmacy,Southwest Hospital,Third Military Medical University,Chongqing,China 400038) |
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| Abstract: | Objective To establish an HPLC method for the determination of triamcinolone acetonide acetate in Compound Triamcinolone Acetonide Acetate Solution.Methods The chromatographic system consisted of C18 column and the mobile phase of acetonitrile-water（60：40）,with the detection wavelength at 240 nm.The flow rate was 1.0 mL /min.The column temperature was 30 ℃,the sample size was 10 μL.Results The linear range was 5.88-15.68 μg（r = 0.999 9）,RSD of inter-and intra-day was less than 2%,and the average recovery rate was 100.43%（n = 9）.Conclusion Without complicated sampling procedure,the method is simple,accurate and repeatable for the assay of the components in this pharmaceutical formulation. |
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| Keywords: | triamcinolone acetonide acetate Compound Triamcinolone Acetonide Acetate Solution HPLC content determination |
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