| 血小板反应素-1在前列腺癌患者中的表达及意义 |
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| 引用本文： | 宋明山,刘志峰,阮政. 血小板反应素-1在前列腺癌患者中的表达及意义[J]. 现代泌尿外科杂志, 2011, 16(4): 349-351,354 |
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| 作者姓名： | 宋明山 刘志峰 阮政 |
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| 作者单位： | 泰安市中心医院泌尿外科，山东泰安，271000 |
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| 基金项目： | 泰安市科技局资助课题(No.20071027) |
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| 摘 要： | 摘要：目的探讨血小板反应素1（TsP一1）在前列腺癌患者癌组织及其外周血中的表达及其意义。方法应用免疫组化技术检测TSP-1在前列腺癌组织（前列腺癌组）中的表达；以半定量RTPCR技术检测TSP-lmRNA在患者外周血中的表达，并与前列腺增生患者（前列腺增生组）进行比较。结果前列腺癌组TSP-1阴性表达6例，弱阳性表达16例，阳性表达4例，增生组TSP-1弱阳性表达12例，阳性表达16例，无阴性表达，前列腺癌组TSP-1表达强度较增生组显著降低（P〈O．01）；TSP-1mRNA在前列腺癌组织中较前列腺增生组织中表达明显下调（P〈0．01）。TSPlmRNA在前列腺癌组外周血中的表达较增生组明显下调（P〈o．01）。结论TSP-1基因及蛋白表达水平在前列腺癌组织中明显下调，在前列腺癌患者外周血中表达水平明显下调。
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| 关 键 词： | 血小板反应素 前列腺癌 免疫组化 逆转录多聚酶链反应 基因 |
Expression and clinical significance of thrombospondin-1 in human prostate cancer |
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| SONG Ming-shan,LIU Zhi-feng,RUAN Zheng. Expression and clinical significance of thrombospondin-1 in human prostate cancer[J]. Journal of MOdern Urology, 2011, 16(4): 349-351,354 |
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| Authors: | SONG Ming-shan LIU Zhi-feng RUAN Zheng |
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| Affiliation: | SONG Ming-shan,LIU Zhi-feng,RUAN Zheng(Department of Urology,Central Hospital of Taian City,Taian 271000,China) |
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| Abstract: | Objective To investigate the relationship between thrombospodin-1 expression and the development of human prostate cancer and its clinical significance.Methods The expression of TSP-1 in 26 cases of prostate cancer tissues and 28 hyperplastic prostate tissues,and the expression of TSP-1 mRNA in the peripheral blood of patients with prostate cancers were detected with immunohistochemistry methods and semi-quantitive RT-PCR.The relationship between the expression of TSP-1 and the clinic pathological features ... |
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| Keywords: | thrombospondin prostate cancer immunohistochemisty RT-PCR gene |
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