Contribution of supraspinal and spinal structures to the responses of dorsal spinal cord blood flow to innocuous cutaneous brushing in rats |
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Authors: | Kurosawa Mieko Toda Hiroko Watanabe Orie Budgell Brian |
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Institution: | Center for Medical Science, International University of Health and Welfare, Otawara, Tochigi 324-8501, Japan. mieko-ku@iuhw.ac.jp |
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Abstract: | Responses of dorsal spinal cord blood flow (SCBF) to innocuous mechanical cutaneous stimulation were investigated in anesthetized central nervous system intact (CNS-intact) and C2 spinalized rats. SCBF was recorded at the L4-L6 level with a laser Doppler flowmeter. SCBF increased with brushing of the ipsilateral proximal hindlimb and hindpaw, and there were no significant differences in the magnitudes of the responses in CNS-intact and spinalized animals. Brushing of the lower back had no effect on SCBF at the L4-L6 level in either cohort. Brushing stimulation produced no significant changes in systemic arterial blood pressure. The responses of SCBF to brushing in CNS-intact animals were diminished by pretreatment with phenoxybenzamine, an alpha-adrenoceptor blocking agent, but no such effects were seen in spinalized animals. These results indicate that innocuous mechanical cutaneous input can produce a segmentally-organized increase in regional SCBF, and that the responses are modulated, in part at least, by alpha-adrenergic receptors via supraspinal structures. |
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