顺铂腹腔内滴灌联合全身化疗治疗晚期胃癌

目的:研究顺铂腹腔内滴灌配合草酸铂联合亚叶酸钙(CF)及氟尿嘧啶(5-Fu)全身化疗治疗晚期胃癌的疗效。方法:对入选的65例晚期胃癌患者以草酸铂联合亚叶酸钙(CF)及氟尿嘧啶(5-Fu)双周方案给予全身化疗,并配合每周1次顺铂(DDP)单药腹腔灌注化疗。结果:完成治疗的60例患者中,CR4例,PR34例,总有效率(RR:CR PR百分率)为63%;各种病理分型均有较好疗效;从转移的情况来看,对伴有腹水者疗效较好。结论:顺铂腹腔内滴灌配合草酸铂联合亚叶酸钙(CF)及氟尿嘧啶(5-Fu)全身化疗治疗晚期胃癌,疗效可靠,毒副反应可以耐受,值得临床推广应用。

Intraperitoneal Perfusion of Cisplatin Plus Systemic Chemotherapy for Advanced Carcinoma of Stomach

OBJECTIVE: To study the efficacy of intraperitoneal perfusion of cisplatin in combination with systemic chemotherapy consisting of oxaliplatin, calcium folinate (CF) and fluorouracil (5-Fu) in treating advanced gastric cancer. METHODS: A total of 65 cases with advanced gastric cancer were administered with cisplatin weekly by intraperitoneal perfusion in combination with systemic chemotherapy consisting of oxaliplatin, calcium Folinate and fluorouracil (5-Fu) for 2 weeks. RESULTS: Of the 60 cases who had finished their treatment, the total effective rates were 63 percent(RR: CR plus PR (%)),4 cases for CR and 34 for PR. Pathological typings revealed satisfactory efficacy. Regarding metastasis, patients complicated with ascites showed satisfactory outcome. CONCLUSION: Intraperitoneal perfusion of cisplatin in combination with systemic chemotherapy consisting of oxaliplatin, calcium folinate and fluorouracil (5-Fu) is reliable in efficacy, tolerant in toxic adverse reactions, and which thus deserves to be widely adopted in the clinic.