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An Engineering Model of Dynamic Cardiomyoplasty. II. Clinical Applications |
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| Authors: | Frederick Y Chen Lishan Aklog Brian J deGuzman David B Lautz Rashid M Ahmad Rita G Laurence Gregory S Couper Lawrence H Cohn Thomas A McMahon |
| Institution: | (1) Division of Engineering and Applied Sciences, Harvard Graduate School of the Arts and Sciences, Harvard-MIT Division of Health, Sciences, and Technology, Cambridge, MA;(2) Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA |
| Abstract: | Previously, a modification to the Sunagawa engineering model for the isolated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty patients, we predicted human stroke volume using the model with human clinical data from the literature. Predicted stroke volume correlated well with published stroke volume in patients who have had the dynamic cardiomyoplasty procedure. These results suggest that the modest hemodynamic improvement commonly reported after the procedure is performed may be due to diminished latissimus dorsi strength after transformation. The validity of both the original Sunagawa model and the previously proposed modification for dynamic cardiomyoplasty is further supported with these results. A nomogram methodology for predicting stroke volume after dynamic cardiomyoplasty for any particular patient is presented. |
| Keywords: | Clinical cardiomyoplasty Nomogram Muscle transformation Model Cardiomyoplasty Applications |
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