Cellular screening assays using fluorescence microscopy. |
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Authors: | R A Blake |
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Institution: | Sugen Inc., South San Francisco, CA 94080-4811, USA. robert-blake@sugen.com |
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Abstract: | The recent development of automated fluorescence imaging systems has enabled fluorescence microscopy to be used for the purposes of compound screening. This information-rich technique has found various applications, including screening for the effect of kinase inhibitors on the cytoskeleton, agonist-stimulated receptor internalization, and protein phosphorylation and acetylation. The discovery of novel fluorescent proteins and new fluorescent dyes will find many applications in multichannel fluorescence imaging assays. |
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