Reconstitution of the central and peripheral nervous system during salamander tail regeneration |
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Authors: | Levan McHedlishvili Vladimir Mazurov Kathrin S Grassme Kerstin Goehler Bernhard Robl Akira Tazaki Kathleen Roensch Annett Duemmler Elly M Tanaka |
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Institution: | Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. |
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Abstract: | We show that after tail amputation in Ambystoma mexicanum (Axolotl) the correct number and spacing of dorsal root ganglia are regenerated. By transplantation of spinal cord tissue and nonclonal neurospheres, we show that the central spinal cord represents a source of peripheral nervous system cells. Interestingly, melanophores migrate from preexisting precursors in the skin. Finally, we demonstrate that implantation of a clonally derived spinal cord neurosphere can result in reconstitution of all examined cell types in the regenerating central spinal cord, suggesting derivation of a cell with spinal cord stem cell properties. |
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Keywords: | neural stem cell segmentation Hox |
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