| 安妥明对高胆固醇血症大鼠血脂、LCAT及过氧化酯质的影响 |
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| 引用本文： | 关利新,吕怡芳. 安妥明对高胆固醇血症大鼠血脂、LCAT及过氧化酯质的影响[J]. 吉林大学学报(医学版), 1992, 0(3) |
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| 作者姓名： | 关利新 吕怡芳 |
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| 作者单位： | 白求恩医科大学药理教研室，牡丹江医学院 |
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| 摘 要： | 本实验探讨安妥明对实验性高胆固醇血症大鼠脂质代谢紊乱的影响。实验结果表明安妥明除具有已知的降低血清T—C、LDL—C和VLDL—C作用外,还可明显升高高胆固醇血症大鼠的血清HDL—C水平和LCAT活性,同时能明显降低血清及肝脏IPO的形成。进一步观察表明,安妥明对高密度脂蛋白亚组份的作用是使HDL_2-C升高,而对HDL_3-C无明显影响。
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| 关 键 词： | 安妥明 高密度脂蛋白—胆固醇 卵磷脂胆固醇酰基转移酶 过氧化脂质 |
EFFECT OF CLOFIBRATE ON METABOLISM OF LIPOPROTEIN -CHOLESTEROL IN RATS |
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| Guan Lixin,Lu Yifang. EFFECT OF CLOFIBRATE ON METABOLISM OF LIPOPROTEIN -CHOLESTEROL IN RATS[J]. Journal of Jilin University: Med Ed, 1992, 0(3) |
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| Authors: | Guan Lixin Lu Yifang |
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| Affiliation: | Dept of Pharmadl; Postgraduate |
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| Abstract: | The effect of clofibrate on lipemia and LCAT as well as LPO in hypercholesteremic rats was observed. Clofibrate not only had the effect decreasing serum T-C, LDL -C and VLDL -C, but also could significantly increase serum HDL-C and the activily of LCAT. It could significantly decrease the formation of LPO in serum and liver as well. AS to the action of clofibrate on HDL sub-fraction, we found that it was HDL2 -C but not HDL3 -C that was mainly affected. |
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| Keywords: | Clofibrat High density Lipoproteim - cholesterol (HDL - C) Lecithin -cholesterol acyltransferase ( LCAT ) Lipid peroxide ( LPO ) |
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