Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species |
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Authors: | Pimenta Eli F Vita-Marques Aline M Tininis Aristeu Seleghim Mirna H R Sette Lara D Veloso Katyuscya Ferreira Antonio G Williams David E Patrick Brian O Dalisay Doralyn S Andersen Raymond J Berlinck Roberto G S |
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Affiliation: | Instituto de Qui?mica de Sa?o Carlos, Universidade de Sa?o Paulo, CP 780, CEP 13560-970, Sa?o Carlos, SP, Brazil. |
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Abstract: | A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites. |
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