| 怡心饮对糖尿病心脏病大鼠心肌CTGF-mRNA和MCP-lmRNA表达的影响 |
| |
| 引用本文： | 王海颖,陈城,陆敏,鲍君璐.怡心饮对糖尿病心脏病大鼠心肌CTGF-mRNA和MCP-lmRNA表达的影响[J].中医药研究,2012(9):1086-1088. |
| |
| 作者姓名： | 王海颖 陈城 陆敏 鲍君璐 |
| |
| 作者单位： | 上海中医药大学,201203 |
| |
| 基金项目： | 上海市科委自然科学基金项目（No.10ZRl428600）;上海市教委方剂学重点学科建设项目子项目（No.z09011-03） |
| |
| 摘 要： | 目的观察怡心饮对糖尿病心脏病大鼠心脏单核趋化因子1（MCP-1）和结缔组织生长因子（CTGT）mRNA表达的影响。方法运用高糖高脂饲料加链脲佐茵素腹腔注射建立大鼠2型糖尿病心肌病模型，分为怡心饮高剂量组、怡心饮低剂量组、生脉饮对照组、正常组、模型组。灌胃治疗8周后，观察糖尿病心肌病大鼠的心脏单核趋化因子1和结缔组织生长因子mRNA的表达，以及血清结缔组织生长因子的变化，分析其减轻大鼠心肌病变的机制。结果怡心饮能明显降低大鼠心肌单核趋化因子1和结缔组织生长因子ITIRNA表达，降低大鼠血清结缔组织生长因子含量。结论怡心饮对糖尿病大鼠心肌病变有一定的改善作用，其作用机制可能与降低单核趋化因子1和结缔组织生长因子mRNA的表达有关。
|
| 关 键 词： | 怡心饮 结缔组织生长因子 单核趋化因子1 糖尿病 大鼠 |
Effect of Yixin Yin on Expression of CTGF mRNA and MCP 1 mRNA of Myocardium in Diabetic Cardiomyopathy Rats |
| |
| Institution: | Wang Haiying,Chen Cheng,Lu Min,(et al // Shanghai University of Tradional Chinese Medicine (Shanghai 201203)) |
| |
| Abstract: | Objective To investigate the influence of Yixin Yin on the expression of connective tissue growth factor （CTGF） and monocyte chemotactic protein 1 （MCP 1） of diabetes mellitus（DM） rats and its protective mechanism. Methods Rats with type 2 DM（T2DM） cardiomyopathy model was established by high sugar,fat feed and chain bacteria intraperitoneal injection of urea. Rats were divided into the Yixin Yin high dose group, low dose group, Shengmai Yin control group, normal group, and model group. Af ter treatment for 8 weeks, myocardial MCP 1 mRNA and CTGF mRNA expression were observed. Results The levels of myocardi al MCP 1 mRNA,CTGF mRNA expression and serum CTGF were Significantly decreased in Yixin Yin groups. Conclusion Yixin Yin could reduce the expression of myocardial CTGF mRNA and MCP 1 mRNA in DM rats with cardiomyopathy. |
| |
| Keywords: | Yixin Yin connective tissue growth factor monocyte chemotactic protein diabetes mellitus |
| 本文献已被 维普 等数据库收录！ |
