Successful management of anti-GBM disease in a 5 1/2-year-old girl. |
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| Authors: | Sevcan Azime Bakkaloglu Cigdem Seher Kasapkara Oguz Soylemezoglu Harun Peru Kibriya Fidan Enver Hasanoglu Necla Buyan |
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| Institution: | Gazi University Hospital, Department of Pediatric Nephrology, Besevler 06500, Ankara, Turkey. sevcan@gazi.edu.tr |
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| Abstract: | |
Introduction
| Anti-glomerular basement membrane (anti-GBM) antibody diseaseis a rare autoimmune disorder characterized by rapidly progressiveglomerulonephritis with crescentric changes that affect mostglomeruli 1–3]. It is defined by the presence of autoantibodiesdirected at specific antigenic targets within the glomerularand/or pulmonary basement membrane. These antibodies bind tothe  -3 chain of type IV collagen found in these specializedmembranes. It is the cause in 10–20% of patients withcrescentric glomerulonephritis 4,5]. All age groups are suggestedto be affected, but the peak incidence is in the third decadein young men and a second peak is in the sixth and seventh decades,affecting men and women equally. Isolated renal disease is morefrequent in the elderly 2]. Although rapidly progressive glomerulonephritisin childhood is quite uncommon, we observed anti-GBM
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| Keywords: | anti-GBM disease cerebral vasculitis children management |
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