| 肝移植术后人工肝支持疗法对免疫抑制药血药浓度的影响 |
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| 引用本文： | 计勇,甄作均,许卓明,苏树英,陈焕伟.肝移植术后人工肝支持疗法对免疫抑制药血药浓度的影响[J].岭南现代临床外科,2004,4(2):83-84. |
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| 作者姓名： | 计勇 甄作均 许卓明 苏树英 陈焕伟 |
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| 作者单位： | 佛山市第一人民医院肝胆外科,佛山,528000 |
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| 摘 要： | 目的观察肝移植术后非生物型人工肝支持系统的应用对免疫抑制药血药浓度的影响及其产生的后果。方法2例患者在肝移植术后因各种不同原因分别行非生物型人工肝3—4次。治疗前后分别测定环孢霉素(CSA)浓度，依测定结果，调整CSA用量。结果每次人工肝支持疗法后，CSA浓度均明显下降。1例患者出现急性排斥反应而死亡。结论人工肝支持疗法对肝移植术后免疫抑制药血药浓度影响显著，增加排斥反应发生的机会。
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| 关 键 词： | 肝移植 人工肝支持系统 免疫抑制药 血药浓度 环孢霉素 排斥反应 |
| 文章编号： | 1009-976X(2004)02-0083-02 |
| 修稿时间： | 2003年9月27日 |
Effects of artificial liver supporting treatment on the blood concentration of immunosuppressive drug after liver transplantation |
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| Abstract: | Objective To observe the effect and consequence of using non biologic type artificial liver supporting system(NBALSS)on the blood concentration of immunosuppressive drug after orthotopic liver transplantation(OLT).Methods Two patients received 3 to 4 times of NBALSS after OLT because of different causes.The concentration of cyclosporine was determinated respectively before and after treatment.Aecording to the results of determination,the dose of cyclosporine A(CSA) was regulated.Results The concentration of CSA was declined obviously in every time after artificial liver supporting treatment.1 case died from acute rejection.Conclusion Effects of artificial liver supporting treatment are obvious on the blood concentration of immunosuppressive drug after liver transplantation and it can increase the opportunity of rejection. |
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| Keywords: | Liver transplantation Artificial liver supporting system Cyclosporine |
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