| 丹参酮ⅡA磺酸钠注射液配伍稳定性考察 |
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| 引用本文： | 王丰伟,涂安娜.丹参酮ⅡA磺酸钠注射液配伍稳定性考察[J].海峡药学,2010,22(4):15-17. |
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| 作者姓名： | 王丰伟 涂安娜 |
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| 作者单位： | 1. 浙江省瑞安人民医院药剂科,瑞安,325200
2. 温州医学院,温州,325035 |
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| 摘 要： | 目的考察丹参酮ⅡA磺酸钠注射液分别与果糖注射液、果糖氯化钠注射液、转化糖注射液的配伍稳定性。方法分别观察及测定30E条件下，6h内各配伍液的外观、PH值变化．并采用高效液相色谱法（HPLC）测定各配伍液中丹参酮ⅡA的含量变化。结果在30E条件下．丹参酮ⅡA磺酸钠注射液与果糖注射液等配伍后，6h内各配伍液的外观、PH值及丹参酮ⅡA的含量均无明显变化。结论丹参酮ⅡA磺酸钠注射液与果糖注射液等配伍6h内基本稳定。
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| 关 键 词： | 丹参酮ⅡA磺酸钠注射液 高效液相色谱法（HPLC） 配伍稳定性 |
Study on the stability of sulfotanshinone sodium injection in three transfusions |
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| WANG Feng-wei,TU An-na.Study on the stability of sulfotanshinone sodium injection in three transfusions[J].Strait Pharmaceutical Journal,2010,22(4):15-17. |
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| Authors: | WANG Feng-wei TU An-na |
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| Institution: | 1. Ruian People＇ s Hospital, Wenzhou 325200 ; 2. wenzhou medical college, wenzhou 32500, China) |
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| Abstract: | OBJECTIVE To investigate the stability of sulfotanshinone sodium injection in fructose injection, fructose and sodium chloride injection, invertose injection. METHODS The observation was made to see the appearance and the pH value of each mixture solution at the temperature of 30℃ with 6 hours. Meanwhile, the content of tanshinone ⅡA in each solution was determined by HPLC method. RESULTS Under the temperature of 30℃, there were almost no changes in the appearance, the pH value and the content of tanshinone ⅡA in each compatible solution within 6 hours. CONCLUSION The quality of sulfotanshinone sodium injection in each compatible solution is stable within 6 hours. |
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| Keywords: | sulfotanshinone sodium injection high performance liquid chromatography （HPLC） stability |
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