Stem cells and cancer |
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| Authors: | Houghton JeanMarie Morozov Alexei Smirnova Iva Wang Timothy C |
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| Affiliation: | Department of Medicine, GI Division, University of Massachusetts Medical School, LRB-Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605-2324, United States. jeanmarie.houghton@umassmed.edu |
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| Abstract: | The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma. |
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