辛伐他汀对2型糖尿病高脂血症的疗效

目的 :探讨辛伐他汀 2 0 mg/ d治疗 2型糖尿病高脂血症的疗效及安全性。方法 :6 0例 2型糖尿病高脂血症患者随机分为 2组 ,各 30例。分别予辛伐他汀 1片 (每片 5 mg或 2 0 mg) ,qn,用药 4wk。结果 :辛伐他汀 2 0 mg/ d组降低 TC 33% ,降低 L DL - C 46 % ,降低 TG 2 6 % ,升高 HDL - C 2 1% ,且降低 TC/ HDL - C 44 %。组间比较 ,2组的血清 TG、L DL - C降低幅度及HDL - C上升幅度有显著性差异 (P<0 .0 1) ,TC降低幅度无明显差异 (P>0 .0 5 )。对血糖水平无不良影响。结论 :2 0 m g/ d治疗2型糖尿病高脂血症患者安全、有效。

Clinical efficacy of simvastatin in treating hyperlipidemia in the type 2 diabetes

AIM: To evaluate the curative efficacy and safety of treating the type 2 diabetic hyperlipidemia with simvastatin 20 mg/tablet. METHODS: Sixty patients of type 2 diabetes hyperlipidemia were divided randomly into 2 groups. Thirty patients separately were given simvastatin orally 5 mg/tablet (LDL) or 20 mg/tablet in evening for 4 wk. RESULTS: Simvastatin 20 mg/tablet reduced serum total cholesterol (TC) 33%, reduced low density lipoprotein (LDL) 46%, reduced triglycerides (TG) 26%, rose high density lipoprotein (HDL) 21%, and reduced TC/HDL C 44%. Comparasion of 2 groups, area of reduced TG and LDL C and area of rose HDL C had remarkable differences ( P <0 01), area of reduced TC had no remarkable differences ( P >0 05). It had no effect on blood glucose. CONCLUSION: Simvastatin 20 mg/tablet is one of the safe and effective drugs to treat hyperlipidemia of the type 2 diabetes.