| 莲心碱在大鼠体内的药物动力学研究 |
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| 引用本文： | 许磊,王淑君,陈济民,姚崇舜.莲心碱在大鼠体内的药物动力学研究[J].沈阳药科大学学报,2001,18(4):244-246. |
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| 作者姓名： | 许磊 王淑君 陈济民 姚崇舜 |
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| 作者单位： | 沈阳药科大学药学院 |
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| 摘 要： | 用反向HPLC法 ,以己酮可可碱为内标 ,建立了血浆中莲心碱的测定方法 ,血浆标准曲线为A1/A2 =0 3188C - 0 0 6 77,相关系数r =0 9999,回收率及日内、日间精密度均符合要求。根据大鼠颈静脉给药 (8 5 4mg/kg)后测得的血药浓度 ,用 3P87处理后求得的莲心碱的主要药动学参数为 :t1/ 2 (α) =2 5 14min ,t1/ 2 ( β) =49 5 2 2min ,AUC =114 878min·μg/mL ,CL =0 0 743L/ (kg·min) -1,V(c) =0 76 6L/kg。
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| 关 键 词： | 莲心碱 反向HPLC法 血浆 大鼠 药物动力学 |
| 文章编号： | 1006-2858(2001)04-0244-03 |
| 修稿时间： | 2000年11月14 |
The pharmacokinetic research on Liensinien in rats |
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| XU Lei,WANG Shu jun,Chen Ji min,YAO Chong shun.The pharmacokinetic research on Liensinien in rats[J].Journal of Shenyang Pharmaceutical University,2001,18(4):244-246. |
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| Authors: | XU Lei WANG Shu jun Chen Ji min YAO Chong shun |
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| Abstract: | A sensitive method of reverse phase high performance liquid chromatography (RP HPLC) for determination of liensinine in plasma was developed. Pentoxifylline was used as the internal standard. The standard curve of liensinine was A 1/A 2= 0 318 8C - 0 067 7 with r = 0 999 9 . The recovery and the precision of intra day and inter day for liensinine was qualified. After iv injection of liensinine in rats, the concentration in rats plasma was detected. Calculated by 3p87,the main pharmacokinetic parameters were as follows: t 1/2(α) = 2 514 min , t 1/2(β) = 49 522 min ,AUC= 114 878 min·μg·mL -1 ,CL= 0 074 3 L·kg -1 ·min -1 , V (c) = 0 766 L·kg -1 . |
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| Keywords: | liensinine RP HPLC plasma rat pharmacokinetics |
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