Coagulation and fibrinolytic activity in patients with acute cerebral infarction |
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Authors: | Li Feng Zhang Guibin Zhao Wenzhou |
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Institution: | 1. Department of Neurology, People's Hospital, Wuhan University, Wuhan 430060, China 2. Department of Neurology, First People's Hospital of Xiangfan, Hubei Province 441000, China |
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Abstract: | Objective To measure the concentration of D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance.
Methods The concentrations of D-dimer, t-PA, and PAI-1 in plasma and cerebrospinal fluid in patients were measured by enzyme-linked immunosorbent assay (ELISA). The PLG biological activity was detected using the chromophore method. The results were compared with those of the controls.
Results The concentrations of D-dimer, t-PA and PAI-1 in cerebrospinal fluid and plasma in patients with acute cerebral infarction were much higher than those of normal subjects (P<0.01). Conversely, the level of PLG activity was significantly lower in the patients than in the controls (P<0.01).
Conclusion Hypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction. |
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Keywords: | Infarction D-dimer tissue plasminogen activator plasminogen activator inhibitor plasminogen coagulation fibrinolytic activity |
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