| Expressions of cyclin E, cyclin dependent kinase 2 and p57~(KIP2) in human gastric cancer |
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| 引用本文： | 梁斌,王杉,杨晓东,叶颖江,于永祥,崔志荣. Expressions of cyclin E, cyclin dependent kinase 2 and p57~(KIP2) in human gastric cancer[J]. 中华医学杂志(英文版), 2003, 116(1) |
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| 作者姓名： | 梁斌 王杉 杨晓东 叶颖江 于永祥 崔志荣 |
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| 作者单位： | Department of Surgery and Laboratory of Surgical Oncology，Department of Surgery and Laboratory of Surgical Oncology，Department of Surgery and Laboratory of Surgical Oncology，Department of Surgery and Laboratory of Surgical Oncology，Department of Surgery and Laboratory of Surgical Oncology，Department of Surgery and Laboratory of Surgical Oncology Peking University People's Hospital，Beijing 100044，China，Peking University People's Hospital，Beijing 100044，China，Peking University People's Hospital，Beijing 100044，China，Peking University People's Hospital，Beijing 100044，China，Peking University People's Hospital，Beijing 100044，China，Peking University People's Hospital，Beijing 100044，China |
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| 摘 要： | Ｔｈｅｍｏｒｂｉｄｉｔｙａｎｄｍｏｒｔａｌｉｔｙｏｆｇａｓｔｒｉｃｃａｎｃｅｒｈａｖｅｄｅｃｒｅａｓｅｄｍａｒｋｅｄｌｙｓｉｎｃｅｔｈｅ 1930’ｓ 1 Ａｌｔｈｏｕｇｈｔｈｉｓｄｅｃｒｅａｓｅｈａｓｏｃｃｕｒｒｅｄｗｏｒｌｄｗｉｄｅ ,ｔｈｅｍｏｒｂｉｄｉｔｙａｎｄｍｏｒｔａｌｉｔｙｏｆｇａｓｔｒｉｃｃａｎｃｅｒａｒｅｓｔｉｌｌｃｏｍｐａｒａｔｉｖｅｌｙｈｉｇｈｅｒｉｎＪａｐａｎ ,Ｃｈｉｎａ ,Ｃｈｉｌｅ ,ａｎｄＩｒｅｌａｎｄ Ｇａｓｔｒｉｃｃａｎｃｅｒｉｓｓｔｉｌｌｔｈｅｌｅａｄｉｎｇｃａｕｓｅｏｆｃ…
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| 关 键 词： | stomach neoplasms · cyclin E · cyclin dependent kinase 2 · cyclin-dependent kinase inhibitor |
Expressions of cyclin E, cyclin dependent kinase 2 and p57KIP2 in human gastric cancer |
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| LIANG Bin,WANG Shan,YANG Xiaodong,YE Yingjiang,YU Yongxiang and CUI Zhirong. Expressions of cyclin E, cyclin dependent kinase 2 and p57KIP2 in human gastric cancer[J]. Chinese medical journal, 2003, 116(1) |
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| Authors: | LIANG Bin WANG Shan YANG Xiaodong YE Yingjiang YU Yongxiang CUI Zhirong |
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| Affiliation: | Department of Surgery and Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing 100044, China |
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| Abstract: | Objective To investigate the expressions of cyclin E, cyclin dependent kinase 2(CDK-2)and cyclin-dependent kinase inhibitor p57 KIP2 in human gastric cancer, and to evaluate the relationships between protein levels and clinicopathological parameters. Methods Western blot was used to measure the expressions of cyclin E, CDK-2 and p57 KIP2 proteins in the surgically resected gastric carcinoma, adjacent normal mucosa and metastatic lymph nodes from 36 patients. Results Cyclin E and CDK-2 protein levels were higher in gastric cancer tissues in comparison with normal tissues (P<0.05). Overexpression of cyclin E was correlated with lymph node involvement, poor histological grade and serosa invasion (P<0.05). Overexpression of CDK-2 was correlated with lymph nodes involvement (P<0.05). No statistically significant difference between cyclin E and CDK-2 expression was found when samples were stratified according to tumor size (P>0.05). Expression of cyclin E and CDK-2 showed a positive linear correlation (r=0.451, P=0.01). Protein levels of p57 KIP2 were lower in gastric cancer tissues than in the normal mucosa (P<0.05). Decreased expression of p57 KIP2 was correlated with lymph node involvement (P<0.05). No statistically significant difference in p57 KIP2 expression was found when sample were stratified according to tumor size, histological grade or serosa invasion (P>0.05). In metastatic lymph nodes, expression of cyclin E was increased and the expression of p57 KIP2 decreased. Conclusion Overexpressions of cyclin E, CDK-2 and downregulated expression of p57 KIP2 may play important roles in tumorigenesis and metastatic potential of gastric cancer. |
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| Keywords: | stomach neoplasms cyclin E cyclin dependent kinase 2 cyclin-dependent kinase inhibitor |
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