Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment |
| |
Authors: | Jia Hongyu Du Jie Zhu Sihe Ma Yingji Cai Huafeng |
| |
Affiliation: | 1. The Immunological Department, Institute of Infectious Diseases of the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, China 2. The Department of Pharmacology of Harbin Medical University, Harbin 150086, China 3. The Department of Infectious Diseases of the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China |
| |
Abstract: | To discuss the roles of serum interleukin-18 (IL-18), interleukin-10 (IL-10) and soluble interleukin-2R (sIL-2R) in the pathogenesis of chronic hepatitis C and to observe the effects of interferon (IFN) on the above- mentioned serum cytokines Methods The levels of above- mentioned cytokines were detected in 10 healthy individuals, 24 asymptomatic hepatitis virus C (HCV) carriers and 27 patients with chronic hepatitis C ( before and after IFN treatment) using enzyme linked immunosorbent assay (ELISA) Results The levels of the cytokines in patients with chronic hepatitis C are higher than in healthy people (P<0 05) and in asymptomatic HCV carriers(P<0 05) The values of the cytokines show a significant positive correlation to ALT (P<0 05) Levels of tested cytokines decreased observably after IFN treatment (P<0 05) The grades of the serum levels for sIL-2R and IL-10 before IFN treatment (from high to low) were categorized accordingly: non-response group> partial- response group >complete- response group (P<0 05) Conclusions The tested cytokines co-participate in the pathogenesis of chronic hepatitis C, and can be used to evaluate the effect of IFN on the immune state of organisms Furthermore, sIL-2R and IL-10 are important for predicting the anti-viral efficacy of IFN |
| |
Keywords: | IL-18 IL-10 sIL-2R viral hepatitis C antiviral treatment |
本文献已被 CNKI 万方数据 PubMed 等数据库收录! |
| 点击此处可从《中华医学杂志(英文版)》浏览原始摘要信息 |
|
点击此处可从《中华医学杂志(英文版)》下载全文 |
|