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| A combination of Ang Ⅱ and carbon tetrachloride acce lerates process of hepatic fibrosis | |
| 引用本文： | Zhou X,Li D,Li X,Lu H,Zhang W. A combination of Ang Ⅱ and carbon tetrachloride acce lerates process of hepatic fibrosis[J]. 中华医学杂志(英文版), 2003, 116(1): 62-65 |
| 作者姓名： | Zhou X Li D Li X Lu H Zhang W |
| 作者单位： | [1]DepartmentofGastroenterologyandHepatology,XinHuaHospital,ShanghaiSecondMedicalUniversity,Shanghai200092,China [2]DepartmentofPathology,XinHuaHospital,ShanghaiSecondMedicalUniversity,Shanghai200092,China |
| 摘 要： | Objective To assess whether Angiotensin Ⅱ（Ang Ⅱ）and carbon tetrachloride(CCl4) used in combination could accelerate the process of fibrosis and whether Ang Ⅱ play a role in exaggerating hepatic fibrosis in rats.Methods Ang Ⅱ was injected into the abdominal cavity of Sprague-Dawley(SD) rats together with subcutaneous injection of CCl2.Rats were killed after 14 and 28d.Blood serum and liver specimen were collected.The extent of fibrosis in the stained liver tissue sections was determined with the KS 400 Image Analysis System.Results Rats receiving Ang Ⅱ and CCl4 for 28d showed extensive liver fibrosis.Along with the increase of hepatic fibrosis,the serum concentration of Ang Ⅱ went up gradually.Conclusions A combination of AngⅡ and CCl4 would accelerate the process of hepatic fibrosis.AogⅡ probably took part in the occurrence of heparic fibrosis. |
| 关 键 词： | AngⅡ 血管紧张素Ⅱ 四氯化碳 联合作用 肝纤维化 |
A combination of Ang II and carbon tetrachloride accelerates process of hepatic fibrosis |
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| Zhou Xin,Li Dingguo,Li Xuanhai,Lu Hanming,Zhang Wenzhu. A combination of Ang II and carbon tetrachloride accelerates process of hepatic fibrosis[J]. Chinese medical journal, 2003, 116(1): 62-65 | |
| Authors: | Zhou Xin Li Dingguo Li Xuanhai Lu Hanming Zhang Wenzhu |
| Affiliation: | 1. Department of Gastroenterology and Hepatology, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China 2. Shanghai Second Medical University, Shanghai 200025, China 3. Department of Pathology, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China |
| Abstract: | OBJECTIVE: To assess whether Angiotensin II (Ang II) and carbon tetrachloride (CCl(4)) used in combination could accelerate the process of fibrosis and whether Ang II play a role in exagerating hepatic fibrosis in rats. METHODS: Ang II was injected into the abdominal cavity of Sprague-Dawley (SD) rats together with subcutaneous injection of CCl(4). Rats were killed after 14 and 28 d. Blood serum and liver specimen were collected. The extent of fibrosis in the stained liver tissue sections was determined with the KS 400 Image Analysis System. RESULTS: Rats receiving Ang II and CCl(4) for 28 d showed extensive liver fibrosis. Along with the increase of hepatic fibrosis, the serum concentration of Ang II went up gradually. CONCLUSIONS: A combination of Ang II and CCl(4) would accelerate the process of hepatic fibrosis. Ang II probably took part in the occurrence of heparic fibrosis. |
| Keywords: | fibrosis angiotensin Ⅱ carbon tetrachloride |
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