| Decreased renal vitamin K-dependent γ-glutamyl carboxylase activity in calcium oxalate calculi patients |
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| 作者姓名： | Chen J Liu J Zhang Y Ye Z Wang S |
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| 作者单位： | Department of Urology,Wuhan First Hospital,Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology Wuhan 430022,China,Wuhan 430030,China,Wuhan 430030,China,Wuhan 430030,China,Wuhan 430030,China |
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| 基金项目： | TheworkwassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No .3990 70 740 ) |
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| 摘 要： | Objective To study the activity of vitamin K-dependent γ-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis. Methods Renal parenchymas were harvested from urolithic patients and renal tumor patients undergoing nephrectomy. The renal carboxylase activity was evaluated as the radioactivity of ［14C］ labeled sodium bicarbonate in carboxylic reactions in vitro using β-liquid scintillation counting. Results Significantly reduced activity of renal vitamin K-dependent γ-glutamyl carboxylase was observed in the urolithic group as compared with normal controls (P<0.01). Conclusion It suggests that the reduced carboxylase activity observed in the urolithic patients may play an important role in the course of renal calcium oxalate urolithiasis.
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| 关 键 词： | 肾脏 维生素K依赖性碳酸酵素 草酸钙 泌尿系结石 |
Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients |
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| Chen J,Liu J,Zhang Y,Ye Z,Wang S.Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients[J].Chinese Medical Journal,2003,116(4):569-572. |
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| Authors: | Chen Junhui Liu Jihong Zhang Yongshang Ye Zhangqun Wang Shaogang |
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| Institution: | 1. Department of Urology, Wuhan First Hospital, Wuhan 430022, China
2. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | OBJECTIVE: To study the activity of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis. METHODS: Renal parenchymas were harvested from urolithic patients and renal tumor patients undergoing nephrectomy. The renal carboxylase activity was evaluated as the radioactivity of (14)C] labeled sodium bicarbonate in carboxylic reactions in vitro using beta-liquid scintillation counting. RESULTS: Significantly reduced activity of renal vitamin K-dependent gamma-glutamyl carboxylase was observed in the urolithic group as compared with normal controls (P < 0.01). CONCLUSION: It suggests that the reduced carboxylase activity observed in the urolithic patients may play an important role in the course of renal calcium oxalate urolithiasis. |
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| Keywords: | calcium oxalate urolithiasis vitamin K-dependent carboxylase |
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