氟马西尼治疗严重肝性脑病的临床研究

目的研究氟马西尼治疗严重肝性脑病(Ⅲ、Ⅳ期)的疗效。方法72例Ⅲ、Ⅳ期肝性脑病的患者,在去除诱因,限制蛋白饮食,乳果糖灌肠,门冬氨酸-鸟氨酸降血氨等综合治疗的基础上,随机分成2组,治疗组给予氟马西尼,安慰剂组给予生理盐水。对比观察两组给药前、给药后2h的临床症状和脑电图的改善率,并观察2周后患者的存活率。结果治疗组给药后临床症状改善率为43.6%,脑电图的改善率48.7%,均明显高于安慰剂组;2周后两组患者的存活率大致相同。结论氟马西尼能改善Ⅲ、Ⅳ期肝性脑病患者的意识状态,有催醒作用,并可以消除脑电图异常,但维持时间短,对提高患者的存活率无明显作用。

Clinical study of flumazenil on severe hepatic encephalopathy

Objective To assess the effect of flumazenil on severe hepatic encephalopathy(stage III and IV).Methods72 patients with hepatic encephalopathy(stage III and IV)were randomly divided into 2 groups,the treatment group was treated with flumazenil,and control group was treated with saline.The improvements of clinical symptoms and electroencephalograms 2 hours after treatment were observed,and 2-week survival rates were also calculated.ResultsImprovement rates of clinical symptoms and electroencephalograms were ...