1636例宫颈拭子支原体、衣原体检测及支原体耐药性分析

目的 探讨宫颈沙眼衣原体（CT）、解脲支原体（UU）和人型支原体（MH）的感染情况及了解支原体耐药情况。方法 应用金标法及支原体培养＋药敏分析，对1636例宫颈拭子进行CF、UU和MH三种病原体检测。结果 （1）三种病原体总检出率为49．08％（803／1636）。其中单种病原体检出率为39．06％（639／1636），混合感染率为10.02％（164／1636）；衣原体检出率为11.61％（190／1636）；支原体检出率为37．47％（613／1636）。（2）衣、支原体感染以21～40岁为主，占阳性患者的79．58％。（3）对支原体耐药率最高的是壮观霉素（耐药率〉90％），其中人型支原体及解脲＋人型混合感染者对壮观霉素、罗红霉素、红霉素、阿齐霉素、克拉霉素等耐药率均〉80％；对交沙霉素最敏感，其次是强力霉素。结论 （1）UU、CF、MH是宫颈感染的主要病原体，其感染率依次为UU〉CT〉MH。（2）支原体的耐药菌株较常见，临床治疗应根据药敏结果选择敏感药物。

Analysis on Detection for Chlamydia Trachomatis and Mycoplasma and Drug Resistance of Mycoplasma in 1 636 Cases of Cervical Samples

Objective To investigate the infection rates of Ureaplasma urealyticum(UU),Mycoplasma hominis(MH) and Chlamydia trachomatis(CT) in cervix uteri. Methods The CT, UU and MH were detected in 1636 cases of cervical samples by using the culture for pathogens and golden-standard method. Results (1) The total infection rate of three pathogens was 49.08%(803/1 636), among which the rate of one pathogen infection was 39.06%(639/1 636),and the mixed infection rate was 10.02%(164/1 636); the infection rates of Mycoplasma and Chlamydia trachomatis were 37.47%((613)/(1 636)), and 11.61%(190/1 636) respectively.(2)The high risk age of Mycoplasma and Chlamydia trachomatis infection was from 21 to 40 years, accounted for 79.58% of the positive specimens.(3)The highest drug resistance rate of My-coplasma was actinospectacin (>90%). The drug resistance rates of the Mycoplasma hominis and mixed infection of both UU and MH against actinospectacin,roxithromycin,erythromycin were over 80%. The most sensitive antibiotics was josamycin, the (second) was doxycycline. Conclusion (1)The UU,CT and MH are the major pathogens in female cervix uteri.The range of infection rates from high to low is UU>CT>MH.(2) The drug resistance strains to Mycoplasma is serious. Therefore, we (should) choose the correct antibiotics according to the drug sensitivity test.