初发2型糖尿病患者血清vaspin水平与颈动脉斑块的相关性

目的 探讨初发2型糖尿病(T2DM)患者血清vaspin水平与血糖、血脂、胰岛素抵抗等代谢因素及糖尿病早期颈动脉粥样硬化的关系。方法 选择初发T2DM患者69例，根据有无颈动脉斑块分为糖尿病无斑块组(男17例，女15例)和糖尿病伴斑块组(男20例，女17例)，另外选择年龄、性别相匹配的健康查体者为对照组(男15例，女11例)。测定收缩压(SBP)、腰围(WC)、胰岛素抵抗指数(HOMA IR)等指标，采用ELISA方法测定血清vaspin水平。结果 校正年龄、性别后，糖尿病无斑块组的血清vaspin水平显著高于对照组［(0.66±0.22 ng/mL vs (0.46±0.12)ng/mL，P< 0.01］，而糖尿病伴斑块组血清vaspin水平低于无斑块组［(0.52±0.22)ng/mL vs (0.66±0.22)ng/mL，P<0.05］。偏相关分析显示，血清vaspin与HOMA IR呈负相关(r=-0.276，P=0.025)。Logistic回归分析结果显示，SBP和vaspin水平是糖尿病发生颈动脉硬化的独立相关因素。结论 血清vaspin水平在初发T2DM人群中升高，血清vaspin水平下降可能与初发T2DM患者颈动脉斑块形成有关联。

Association of serum vaspin with carotid plaque in new type 2 diabetic patients

Objective To explore the association of serum vaspin with serum glucose,serum lipid,insulin resistance, and the presence of carotid plaque in early stage of type 2 diabetes.Methods Sixty-nine type 2 diabetic patients with less than 1 year diabetes duration were divided into two groups by the presence or absence of carotid plaque.Twenty-six age-matched healthy controls were recruited as well.Serum vaspin was measured by enzyme-linked immunosorbent assay. Results After age and gender were adjusted,the fasting...