气相色谱法测定枸橼酸莫沙必利中有机溶剂残留量

目的建立气相色谱法测定枸橼酸莫沙必利中有机残留量的方法.方法采用气相色谱法,FID检测器,毛细管色谱柱DB-WAX(30m×0.53 mm,0.5μm),程序升温,载气为氮气,进样口温度200℃,检测器温度260℃,以二甲基亚砜为溶剂配制对照溶液及供试品溶液.结果四种有机溶剂完全分离,在所考察的浓度范围内具有良好的线性,甲醇、乙醇、二氯甲烷、三氯甲烷的检测限分别为3.32,4.15,3.19,3.05μg·mL-1,精密度RSD均小于2.5%.平均回收率为98%～104%.结论经方法学验证,本检测方法简便灵敏,结果准确可靠,适用于枸橼酸莫沙必利原料药中有机溶剂残留量的检测.

Determination of residual solvents in Mosapride Citrate by GC

Obiective To establish a method for the determination of residual solvents in Mosapride Citrate by GC.Methods The detector was FID.The analytical column was DB-WAX（30 m×0.53 mm,0.5 μm）.The injector temperature was 200 ℃,and the detector temperature was 260 ℃.The column temperature was programmed raised.Nitrogen as the carrier gas and the dimethylsulfoxide（DMSO） as solvent media.Results It had a good linearity in the experimental concentration.The detection limit of methanol,ethanol,dichloromethane,trichloromethane separately were 3.32,4.15,3.19,3.05 μg·mL-1.The RSD of precision were all less than 2.5%.The average recovery was 98%～104%.Conclusion this method was simple,sensitive,accurate,and can be used for the detection of four residual solvents in Mosapride Citrate.