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| 依达拉奉对帕金森病小鼠模型黑质酪氨酸羟化酶及Caspase-3的影响 | |
| 引用本文： | 周波,文敏,王文静,何宇红,臧贵勇,焦玲,张春林. 依达拉奉对帕金森病小鼠模型黑质酪氨酸羟化酶及Caspase-3的影响[J]. 山东大学学报(医学版), 2011, 49(12): 58-61 |
| 作者姓名： | 周波 文敏 王文静 何宇红 臧贵勇 焦玲 张春林 |
| 作者单位： | 1. 贵阳医学院人体解剖学教研室,贵阳,550004 2. 贵阳医学院附属医院神经内科,贵阳,550004 3. 贵阳医学院生物学教研室,贵阳,550004 |
| 基金项目： | 贵州省社会发展科学技术攻关计划基金资助项目[黔科合SY字(2008)3046号] |
| 摘 要： | 目的 探讨依达拉奉对帕金森病(PD)小鼠黑质多巴胺神经元的保护作用.方法 30只健康雄性C57BL/6小鼠,随机分为正常对照组、模型组和治疗组.后两组给予腹腔注射百草枯和代森锰建立PD模型.建模成功后,治疗组给予依达拉奉腹腔注射2周,正常对照组给予同剂量生理盐水.观察3组小鼠行为学的变化,并用免疫组织化学法检测黑质TH、Caspase-3的表达.结果 与治疗组比较,模型组小鼠爬杆时间明显延长,黑质TH阳性神经元数量显著降低,Caspase-3的表达显著增高.结论 依达拉奉治疗可使PD小鼠运动能力增强,黑质TH阳性神经元数量增加,并降低Caspase-3的表达,有明显的神经保护作用. |
| 关 键 词： | 帕金森病 依达拉奉 百草枯 代森锰 细胞凋亡 |
Effect of edaravone on tyrosine hydroxylase and caspase-3 in the substantia nigra of the Parkinson's disease mouse model |
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| ZHOU Bo , WEN Min , WANG Wen-jing , HE Yu-hong , ZANG Gui-yong , JIAO Ling , ZHANG Chun-lin. Effect of edaravone on tyrosine hydroxylase and caspase-3 in the substantia nigra of the Parkinson's disease mouse model[J]. Journal of Shandong University:Health Sciences, 2011, 49(12): 58-61 | |
| Authors: | ZHOU Bo WEN Min WANG Wen-jing HE Yu-hong ZANG Gui-yong JIAO Ling ZHANG Chun-lin |
| Affiliation: | ZHOU Bo1,WEN Min1,WANG Wen-jing1,HE Yu-hong1,ZANG Gui-yong1,JIAO Ling2,ZHANG Chun-lin3(1.Department of Anatomy,2.Department of Neurology of Affiliated Hospital,3.Department of Biology,Guiyang Medical University,Guiyang 550004,China) |
| Abstract: | Objective To investigate the protective effect of edaravone on nigrostriatal dopaminergic neurons in Parkinson's disease(PD) mice induced by paraquat(PQ) and maneb(MN).Methods 30 male C57BL/6 mice were randomly divided into the model group,the edaravone-treated group and the normal control group.After the PD mouse model was established by intraperitoneal injection of PQ and MN,mice in the edaravone-treated group were intraperitoneal administrated edaravone for 2 weeks.Motor coordination was detected by usin... |
| Keywords: | Parkinson disease Edaravone Paraquat Maneb Apoptosis |
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