| EGFR和HER2在胶质瘤复发前后表达的变化 |
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| 引用本文： | 贾践博,侯现增,刘滨,许尚臣,庞琦. EGFR和HER2在胶质瘤复发前后表达的变化[J]. 山东大学学报(医学版), 2011, 49(12): 107-110 |
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| 作者姓名： | 贾践博 侯现增 刘滨 许尚臣 庞琦 |
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| 作者单位： | 山东大学附属省立医院神经外科,济南,250021 |
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| 基金项目： | 山东省自然科学基金资助项目(ZR2010HM013) |
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| 摘 要： | 目的 探讨EGFR和HER2在胶质瘤复发中的意义.方法 采用免疫组织化学方法(SABC法)观察24例复发胶质瘤患者原发肿瘤和复发肿瘤组织中EGFR和HER2的表达并与临床治疗指标进行相关分析.结果 复发肿瘤组织较原发肿瘤组织中的EGFR表达减少(P =0.002),复发肿瘤组织较原发肿瘤组织中的HER2表达增加(P=0.006).原发肿瘤中EGFR表达增高和患者无症状生存期呈显著正相关(Spearman等级相关系数r=0.441,P=0.031).复发肿瘤中,EGFR表达增加和首次术后放疗呈正相关(Spearman等级相关系数r=0.446,P=0.029),HER2表达增加和首次术后化疗呈正相关(r=0.438,P=0.032).结论 EGFR和HER2在胶质瘤复发前后的表达有统计学差异,且与术后治疗因素的选择有相关关系.
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| 关 键 词： | 上皮生长因子受体 人表皮生长因子受体2 胶质瘤 肿瘤复发 放疗 |
Expression of EGFR and HER2 in paired primary and recurrent astrocytic tumors |
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| JIA Jian-bo , HOU Xian-zeng , LIU Bin , XU Shang-chen , PANG Qi. Expression of EGFR and HER2 in paired primary and recurrent astrocytic tumors[J]. Journal of Shandong University:Health Sciences, 2011, 49(12): 107-110 |
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| Authors: | JIA Jian-bo HOU Xian-zeng LIU Bin XU Shang-chen PANG Qi |
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| Affiliation: | JIA Jian-bo,HOU Xian-zeng,LIU Bin,XU Shang-chen,PANG Qi(Department of Neurosurgery,Shangdong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China) |
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| Abstract: | Objective To investigate whether EGFR and HER2 were differentially expressed in paired primary and recurrent astrocytic tumors.Methods Protein expression of EGFR and HER2 was investigated by SABC immunohistochemistry.An attempt was made to correlate expression data with clinical treatment factors.Results Decreased EGFR expression(P=0.002) and increased HER2 expression(P=0.006) were observed in recurrent astrocytic tumors compared with primary astrocytic tumors.In primary astrocytic tumors,increased EGFR exp... |
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| Keywords: | Epidermal growth factor receptor Human epidermal growth factor receptor 2 Astrocytic tumour Recurrence Radiotherapy |
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