| 急性白血病患者P-糖蛋白和CD34的表达及其临床意义 |
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| 引用本文： | 林秀梅,谢兆霞,祝平安.急性白血病患者P-糖蛋白和CD34的表达及其临床意义[J].中南大学学报(医学版),2000,25(2):171-172. |
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| 作者姓名： | 林秀梅 谢兆霞 祝平安 |
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| 作者单位： | 湖南医科大学附属湘雅医院血液科!长沙410008(林秀梅，谢兆霞)，衡阳1415医院血液科!衡阳421002(祝平安) |
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| 摘 要： | 用免疫细胞化学ABC法检测 30例急性白血病患者骨髓单个核细胞P 糖蛋白 (P 1 70 )和CD34的表达。结果示 :P 1 70或CD34表达在急性非淋巴细胞白血病组和急性淋巴细胞白血病组之间的差异不明显 ( P >0 .0 5) ;P 1 70或CD34阳性表达组临床疗效差 ,与阴性表达组相比差异明显 (P <0 .0 5)。提示 ,同时检测两者可提高对急性白血病的疗效判断
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| 关 键 词： | 白血病 药物抗药性 糖蛋白 CD34 |
Clinical significance of P glycoprotein and CD34 expression of acute leukemia |
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| LIN Xiu mei ,XIE Zhao xia ,ZHU Ping an.Clinical significance of P glycoprotein and CD34 expression of acute leukemia[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2000,25(2):171-172. |
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| Authors: | LIN Xiu mei XIE Zhao xia ZHU Ping an |
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| Institution: | 1Department of Hematology, Xiangya Hospital, Hunan Medical University(Changsha 410008); 2Department of Hematology, 415 Hospital(Hengyang 421002) [ |
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| Abstract: | The expression of P glycoprotein(P 170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB 1 and Tk 3 monoclonal antibody. The results were that expression of P 170 and CD34 had no signficant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P>0.05). The clinical therapeutic effect was poor in P 170 or CD34 positive patients and had significant difference compared with those negative patients(P<0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P 170 and CD34 simultaneously. |
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| Keywords: | leukemia drug-resistance glycoprotein CD34 |
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