Cerebellar tRNA methyltransferases: A development study |
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Authors: | Jacques Dainat Otto Z. Sellinger |
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Abstract: | Developmental patterns of homologous and heterologous tRNA methylation by cerebellar tRNA methyltransferases are described. The study revealed that: (a) homologous tRNA methylation results in the predominant formation of N2-methyl-guanine and 1-methyladenine; (b) tRNA methyltransferases of bulk-isolated Purkinje and granule cells methylateE. coli tRNAglu2 in vitro in a characteristic manner, and (c) the methylation of 8-day-old cerebellar, cortical and hepatic tRNA in vivo yields tRNAs containing different proportions of methylated bases. The findings suggest that the presumably cell-specific populations of cerebellar tRNA methyltransferases continue to alter their substrate recognition characteristics up to and beyond the first month of post-natal life. |
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Keywords: | cerebellar tRNA methyltransferases developmental study |
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