降纤酶治疗急性脑梗塞的临床及血浆纤溶效果观察

目的：观察降纤酶治疗急性脑梗塞的临床及血浆纤溶效果的变化。方法：对起病超过１２ｈ，小于７２ｈ，ＣＴ证实的３０例脑梗塞患者。静滴降纤酶１０单位，每日１次，连用３日，总量为３０单位，对治疗前后患者的神经功能缺损进行评定，检测血浆Ｄ—二聚体和纤溶酶活性的水平。结果：治疗后患者的临床症状明显改善，血浆Ｄ—二聚体及纤溶酶活性明显升高（Ｐ＜００１）。结论：降纤酶溶栓治疗急性脑梗塞有一定疗效。

A Study of Clinical and Fibrinolytic Effect on Cerebral Infarction With Defibrase Treatment

Objective:To oberve the clinical and fibrinolytic effect of defibrase in the acute cerebral infarction patients,and the alteration of D-dimer concentrations and plasmin activity.Method:30 cases suffered from cerebeal infarction confirmed by CT scan,at the duration of >12 hours and <72 hours after the onset of ischemic stroke,10 unit defibrase was intravenously injected daily.Total dosage is 30 units.After treatment,the scales of neurological parameters were determined and plasma fibrin D-dimer levels and plasmin activity were measured for functional assessment.Results:Patients' conditions improved dramatically,and the D-dimer levels and activity plasmin significantly increased after defibrase treatment ( P <0 001 or P <0 01).Conclusion:Thrombolytic therapy of using defibrase in early cerbral infarction is effective and safe.