| 脑出血周围组织神经微丝和胶质纤维酸性蛋白的变化 |
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| 引用本文： | 王淑荣,孙伟,王德生,孙晓东,臧彩杰,温世荣.脑出血周围组织神经微丝和胶质纤维酸性蛋白的变化[J].哈尔滨医科大学学报,2002,36(6):451-452,456. |
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| 作者姓名： | 王淑荣 孙伟 王德生 孙晓东 臧彩杰 温世荣 |
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| 作者单位： | 1. 哈尔滨医科大学第一临床医学院神经内科,黑龙江,哈尔滨,150001
2. 大庆油田总医院病理科,黑龙江,大庆,163000 |
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| 基金项目： | 黑龙江省自然科学基金资助项目(9804) |
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| 摘 要： | 目的：通过对人脑出血周围组织神经微丝（NF）和胶质纤维酸性蛋白（GFAP）计数与计量观察，研究其病理发展过程。方法：用58例脑出血解剖标本，在血肿周围多方位自血肿壁向外连续取材1．0－2．0cm。采取免疫组化方法观察NF和GFAP的变化。结果：NF损伤程度在血肿周围、双侧皮层、双侧海马区随血肿形成时间延长而加重；GFAP染色强度随血肿形成时间延长而减弱。结论：血肿周围神经元和星形胶质细胞的细胞骨架损伤在脑出血后1周内进行性加重。
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| 关 键 词： | 脑出血 神经微丝 胶质纤维酸性蛋白 细胞骨架 |
| 文章编号： | 1000-1905(2002)06-0451-02 |
Study of neurofilament protein and glial fibrillary acid protein in the zone around the hematoma after intracerebral hemorrhage |
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| WANG Shu-rong,SUN Wei,WANG De-sheng,et al.Study of neurofilament protein and glial fibrillary acid protein in the zone around the hematoma after intracerebral hemorrhage[J].Journal of Harbin Medical University,2002,36(6):451-452,456. |
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| Authors: | WANG Shu-rong SUN Wei WANG De-sheng |
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| Abstract: | Objective By. observing the amount of neurofilament protein(NF) and glial fibrillary acid protein (GFAP) around the hemotoma,to study the pathological coures.Methods Paraffin-embedded train tissues of 58 fatal cases of intracerebral hemorrhage(ICH) from the zone around the hematoma( 1. 0 - 2. 0cm) were used. We examined NF and GFAP by immunohistochemistry. Results The damage degree of NF was related with the age of the hematoma directing,and the intensity of GFAP was related with it inversely. Conclusion In the first week after ICH, the damage of cytoskeletons in neurons and astrocytes become more and more serious. |
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| Keywords: | intracerebral hemorrhage hemarnota neurofilament protein glial fibrillary acid protein cytoskeleton |
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