Three-year study of antibody toBorrelia burgdorferi in Southern Spain |
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Authors: | J. Gutierrez M. C. Maroto A. De la Higuera M. Guerrero E. Padilla G. Piédrola |
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Affiliation: | (1) Department of Microbiology, University Hospital San Cecilio, University of Granada, Granada, Spain;(2) Service of Neurology, University Hospital San Cecilio, University of Granada, Granada, Spain;(3) C/ Camino bajo de Huétor no. 84 1A, 18008 Granada, Spain |
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Abstract: | The prevalence of anti-Borrelia burgdorferi antibodies was studied in Granada, Spain, between January 1991 and November 1993 in 354 patients with suspected Lyme disease (group 1); in 50 patients either with syphilis (n=32) or without syphilis but with a positive Rapid Plasma Reagin test (n=18) (group 2); and in 150 healthy subjects (group 3). In addition, intrathecal antibody production was evaluated by EIA in CSF samples obtained from 117 patients in group 1. Anti-Borrelia burgdorferi antibodies were detected by EIA in 58 patients (16.4 %) in group 1, 29 (8.2 %) of whom were positive by Western blot. Intrathecal antibody production was detected in one patient. In group 2, 8 (16 %) patients had a positive EIA result, but none of these was confirmed by Western blot. Western blot was negative for all subjects in group 3. The results of this study indicate that anti-Borrelia burgdorferi antibodies are not uncommon in our area, although Lyme disease is rare. |
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